Product name:2-Amino-4-methylthiazole

MW: 114.17
Cas No.:1603-91-4


Appearance:yellow solid

Product use:Basic raw materials, organic intermediates, pharmaceutical intermediates

The synthesis process is as follows:
carbon tetrabromide; triethylamine; acetonitrile;

Reactants are commercially availlable.
Tetrahedron Letters, vol. 56, 41, (2015), p. 5623 - 5627 General procedure: To a mixture of ketone (0.5 mmol), thiourea (0.5 mmol), and triethylamine (0.5 mmol) in acetonitrile (3 mL) was added carbon tetrabromide (0.5 mmol) in a round bottom flask at room temperature and the reaction mixture was stirred for 2-6 h. After completion of the reaction (monitored by TLC), water (5 mL) was added and the mixture was extracted with EtOAc (3*5 mL). The combined organic phase was dried over MgSO4, filtered, and evaporated under reduced pressure to give the crude product. The resulting product was purified by silica gel column chromatography using a gradient m ixture of hexane/ethyl acetate as eluent to afford an analytically pure sample of 3.