Product name:3,3-Difluoropiperidine hydrochloride
MF:C5H10ClF2N
Cas No.:496807-97-7
MW:157.59
Structure:

Purity:95%

Product use:Basic raw materials, organic intermediates, pharmaceutical intermediates

The synthesis process is as follows:

hydrogenchloride; hydrogen; methanol; ethanol; palladium on carbon catalyst

Reactants can be synthesized in 1 step.
NOVARTIS PHARMA GMBH, WO2004/69256, A1, (2004) To a solution of 1-benzyl-piperidin-3-one (1G) in CH2CI2 (LOML) is added [bis (2-methoxy- ethyl) amino] SULFER TRIFLUORIDE (1. 84mL) at 0C, and stirred for 1.5hr at room temperature. The reaction mixt ure is poured in aqueous NaHC03 and extracted with ethyl acetate. The organic layer is successively washed with H20 and aqueous NACI, dried over MgS04, and concentrated in vacuo. The residue is purifi ed by column chromatography to give a colorless oil. The oil and Pd/C (5percent w/w on activated carbon, 100MG) in HCI in ETOH/MEOH (50mL) is stirred for 22hr under H2 atmosphere. The reaction mixture is filtrated through celite pad. 4The filtrate is added HCI in EtOAc, then concentrated in vacuo to provide the title compound.